{"id":47,"date":"2017-03-22T20:22:08","date_gmt":"2017-03-22T20:22:06","guid":{"rendered":"http:\/\/papergp.com\/index.php\/down-syndrome\/"},"modified":"2017-07-17T19:34:44","modified_gmt":"2017-07-17T19:34:44","slug":"down-syndrome","status":"publish","type":"page","link":"https:\/\/papergp.com\/index.php\/others\/genetics\/down-syndrome\/","title":{"rendered":"Down syndrome"},"content":{"rendered":"<h5><b>Background:<\/b><\/h5>\n<ul>\n<li>\n<h5><span style=\"font-weight: 400;\">Explanation of DS &#8211; learning difficulties, higher incidence of heart\/GI\/thyroid problems<\/span><\/h5>\n<\/li>\n<li>\n<h5><span style=\"font-weight: 400;\">Explanation of diagnosing before birth &#8211; screening vs diagnostic tests (for high risk &gt;1\/250)<\/span><\/h5>\n<\/li>\n<li>\n<h5><span style=\"font-weight: 400;\">Screening tests &#8211; NT scan, blood tests (between 11-13 weeks)<\/span><\/h5>\n<\/li>\n<li>\n<h5><span style=\"font-weight: 400;\">Diagnostic tests &#8211; amniotic fluid (1% miscarriage, 15 weeks), sample from placenta (2% but can be done earlier &#8211; 11-13weeks)<\/span><\/h5>\n<\/li>\n<li>\n<h5>Approximate risk<\/h5>\n<ul>\n<li>\n<h5>30yo -&gt; 1 in 1000<\/h5>\n<\/li>\n<li>\n<h5>35yo -&gt; 1 in 300<\/h5>\n<\/li>\n<li>\n<h5>40yo -&gt; 1 in 100<\/h5>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h5><b>Data gathering<\/b><\/h5>\n<ul>\n<li>\n<h5><span style=\"font-weight: 400;\">HPC &#8211; Number of pregnancies &#8211; outcomes of previous ones<\/span><\/h5>\n<\/li>\n<li>\n<h5><span style=\"font-weight: 400;\">SH &#8211; job, support at home<\/span><\/h5>\n<\/li>\n<li>\n<h5><span style=\"font-weight: 400;\">FH &#8211; family with DS<\/span><\/h5>\n<\/li>\n<\/ul>\n<h5><b>CM<\/b><\/h5>\n<ul>\n<li>\n<h5><span style=\"font-weight: 400;\">Investigations &#8211; await screening tests<\/span><\/h5>\n<\/li>\n<li>\n<h5><span style=\"font-weight: 400;\">Explanation of DS<\/span><\/h5>\n<\/li>\n<li>\n<h5><span style=\"font-weight: 400;\">Followup &#8211; after screening, PIL<\/span><\/h5>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Background: Explanation of DS &#8211; learning difficulties, higher incidence of heart\/GI\/thyroid problems Explanation of diagnosing before birth &#8211; screening vs diagnostic tests (for high risk &gt;1\/250) Screening tests &#8211; NT scan, blood tests (between 11-13 weeks) Diagnostic tests &#8211; amniotic fluid (1% miscarriage, 15 weeks), sample from placenta (2% but can be done earlier &#8211; &hellip; <a href=\"https:\/\/papergp.com\/index.php\/others\/genetics\/down-syndrome\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Down syndrome<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":43,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-47","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/papergp.com\/index.php\/wp-json\/wp\/v2\/pages\/47","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/papergp.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/papergp.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/papergp.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/papergp.com\/index.php\/wp-json\/wp\/v2\/comments?post=47"}],"version-history":[{"count":5,"href":"https:\/\/papergp.com\/index.php\/wp-json\/wp\/v2\/pages\/47\/revisions"}],"predecessor-version":[{"id":507,"href":"https:\/\/papergp.com\/index.php\/wp-json\/wp\/v2\/pages\/47\/revisions\/507"}],"up":[{"embeddable":true,"href":"https:\/\/papergp.com\/index.php\/wp-json\/wp\/v2\/pages\/43"}],"wp:attachment":[{"href":"https:\/\/papergp.com\/index.php\/wp-json\/wp\/v2\/media?parent=47"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}